Study Results: XPERIENCE Reduces Bacteria, Biofilms

By Julie A. Vetalice

Study Results: XPERIENCE Reduces Bacteria, Biofilms

Next Science reports that XPERIENCE™ No Rinse Solution has been shown to have persistent efficacy against both planktonic bacteria and bacterial biofilms in a new study, “A Novel Irrigant to Eliminate Planktonic Bacteria and Eradicate Biofilm Superstructure With Persistent Effect During Total Hip Arthroplasty.”

The study also found that XPERIENCE produced minimal cytotoxic effects to human tissue, allowing the solution to remain in the body without need for subsequent rinse. Additionally, XPERIENCE – cleared by FDA for U.S. sale in 2021 – was shown to inhibit biofilm formation for up to five hours after application.

Prosthetic joint infection (PJI) remains a significant burden in total hip arthroplasty (THA) and total knee arthroplasty (TKA) in the U.S. Estimates indicate that, by 2030, the annual hospital costs related to PJI of the hip and knee will be $1.85 billion. Interventions to reduce or prevent the occurrence of PJI continue to be at the forefront of research efforts and commercial development.

The study also found that XPERIENCE showed higher in vitro antimicrobial efficacy than three other commercially available adjuvants. The comparative treatments each reduced biofilm in all bacterial strains tested by approximately 1-log or less when the application times in their respective instructions for use were followed. However, XPERIENCE reduced biofilm by approximately 3-log to 8-log when used as directed.

Source: Next Science

Tags: Trial/Study