OrthoPediatrics’ Growing Surgeon Adoption Offsets Headwinds

The company grew in the high single digits for 1Q22 as its non-elective trauma business offset COVID-related elective procedure headwinds.

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Bioventus Focused on Double-Digit Growth and Debt Reduction

The company's orthopedic sales grew 9% organically in 1Q22 as Bioventus targets double-digit organic growth for the full year.

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Enovis Sets Sights on $2 Billion in 2024

The company grew over 60% in 1Q21 as recent acquisitions added momentum to Enovis' already impressive share gains.

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Enovis Acquires 360 Med Care

Australian start-up 360 Med Care provides surgical planning, delivery and rehabilitation services to a worldwide knee and hip replacement market.

CONMED to Acquire In2Bones Global

In2Bones' product portfolio includes implants, fracture systems, biologics and related hardware to treat upper and lower extremities.

Medartis Completes Acquisition of Nextremity Solutions

The move allows Medartis to further accelerate its U.S. extremities business.

ORHub Acquires PUR Biologics

ORHub will enter the medical device market with biologics to regenerate cartilage and address degenerative disc disease and osteoarthritis.

TheraCell Acquired by Isto Biologics

The move will expand Isto's portfolio of procedure-specific allografts for spine, orthopedic and sports medicine applications.

OrthoPediatrics Acquires MD Orthopaedics

The move expands OrthoPediatrics' portfolio with a patented, non-operative solution for the treatment of clubfoot.

Bioventus Exercises Call Option to Acquire CartiHeal

The decision follows FDA's recent premarket approval of CartiHeal's Agili-C implant for the treatment of osteoarthritis.

DePuy Synthes Acquires CUPTIMIZE Hip-Spine Analysis

CUPTIMIZE Hip-Spine Analysis is an x-ray based digital solution that uses patient-specific data to help surgeons assess dislocation risk.

Bioventus Focused on Integrating Recent Acquisitions

The company grew over +28% in 2021, driven in part by synergies from recently acquired Bioness and Misonix.

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Paragon 28 Sets Out to Modernize Foot and Ankle Surgery

The company grew almost 33% in 2021 and expects its focus on medical education and enabling technology will spur further growth.

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Medartis Aims for Leadership Position in Extremities

The company grew +25% in 2022 and took its U.S. business to the next level with the acquisition of Nextremity Solutions.

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Medartis to Acquire Nextremity Solutions

The move expands Medartis' upper and lower extremities business in the U.S. market.

Medtronic Begins Active Portfolio Management Phase

The company's spine business grew in the high single digits for FY 3Q22 as the company prepares to make overall portfolio changes.

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Aurora Spine Partners on Marketing for Patient-Matched Implants

Aurora Spine's DEXA Technology patient-matched implants supported by Echolight's newest technologies in bone health assessment.

OsteoCentric Debuts UnifiMI for Spinal Fusion

Mechanical Integration is designed to address implant instability in normal and compromised bone.

Safe Orthopaedics Collaborates with Brainlab

The companies will co-develop navigation for Safe Orthopaedics' spinal instruments, making them navigable with the Brainlab ecosystem.

NanoHive Medical Partners with Accelus on Distribution

The collaboration pairs Hive Soft Titanium 3D-printed interbody cages with Accelus' FlareHawk and TiHawk expanding interbody fusion devices and Remi robotic navigation.

Exactech Announces Preferred Relationship with Permedica in Spain

Exactech announced a preferred relationship with Permedica to distribute hip replacement products in Spain.

DePuy Synthes Acquires CrossRoads Extremity Systems

CrossRoads is a designer and manufacturer of procedure-specific, sterile-packed implants and instruments for elective foot and ankle surgery.

Bactiguard and Zimmer Biomet Expand License Partnership

Bactiguard and Zimmer Biomet have co-developed implants with the Bactiguard technology, to prevent post-operative infections.

Exactech Partners on the Future of Hip Resurfacing

Exactech and JointMedica will collaborate to deliver the next generation of hip resurfacing with JointMedica's Polymotion hip implant.

Orthopedic Companies Pump Brakes on M&A Activity

M&A transactions increased every year between 2017 and 2020 but slowed considerably in 2021 due to inflated valuations and market disruption.

Smith+Nephew Acquires Engage Surgical, Cementless Partial Knee

Engage Surgical is the owner of the only cementless unicompartmental knee system commercially available in the U.S.

Paragon 28 Acquires Disior, 3D Analytics Pre-operative Planning Software

Disior provides a comprehensive 3D analytics and pre-operative planning platform, and will immediately accelerate internal research programs.

Avanos Medical To Acquire OrthogenRx

OrthogenRx has developed GenVisc and TriVisc viscosupplementation products to treat OA knee pain.

Bioventus Acquisition Pays Off in Third Quarter

The company grew nearly +27% in the third quarter of 2021, with nearly half of that growth attributable to recently acquired Bioness.

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Accelus to Grow via Business Combination

Accelus is focused on the adoption of minimally invasive spinal surgery with implants and a compact precision robotics platform.

Globus Medical Sustains Momentum Through Choppy Market Conditions

The company grew in the mid-single digits for 3Q21 despite orthopedic surgery delays and a strong comparison in the prior year.

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Graftys Acquires Biologics4Life

Biologics4Life is developing a injectable synthetic bone graft materials, complementing Graftys' resorbable calcium phosphate cement.

DePuy Synthes Acquires OrthoSpin

OrthoSpin's automated, digitally-enabled AutoStrut G2 System offers a new solution for the external circular fixation market.

Colfax Pivoting to Medtech Company with New Name: Enovis

Colfax has made strong progress integrating its recent acquisitions, including three foot and ankle businesses.

Bioventus Completes the Acquisition of Misonix

The combined company will operate as a pure-play regenerative medicine and orthopedics company, serving hospital, ASC and office care settings.

OsteoCentric Technologies Acquires Integrity-SI Fusion System

OsteoCentric will apply UnifiMI (Mechanical Integration) to optimize the stability of the Integrity-SI implant.

Tyber Medical to Acquire CatapultMD

The purchase of the contract manufacturer's assets will double Tyber's manufacturing footprint to 100,000 square feet.

Implanet Divesting its Knee Prosthesis to Serf

Implanet will sell the MADISON knee system to SERF and proceed to focus on its spine surgical business.

Bioventus Proceeds with Option Structure Agreement with CartiHeal

The decision signals intent to move forward with an acquisition of CartiHeal and the Agili™-C implant for knee defect repair.

Bioventus Invests in Trice Medical Minimally Invasive Technologies

Bioventus will receive exclusive sales and distribution rights to Trice's handheld arthroscopy and portable ultrasound visualization tools.

What Orthopedic Executives Said About 2Q21

Second-quarter commentary from ortho executives focused on acquisitions, knee replacement sales performance and enabling technology's impact.

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DJO Takes Aim at $1 Billion Recon Business by 2026

In 2Q21, the company drove incremental gains over 2019 as markets continue to recover. DJO expects to be a $1 billion recon player by 2026.

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Bioventus to Acquire Misonix, Enhance Surgical Solutions

The merger will create a company positioned with products and specialized salesforces serving hospital, ambulatory surgical center and office care settings.

The Orthopedic M&A Market: Takeaways for 2021

The COVID-19 pandemic did little to slow the orthopedic market's consolidation. We surveyed the orthopedic merger and acquisition market over the last six years to show why 2020 was a busy year and 2021 may be busier; why spine continues to dominate M&A transactions; and what has driven transactions so far in 2021. These charts, […]

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Integrity Implants and Fusion Robotics Merge to Form Accelus

Accelus to offer procedure-enabling technology with the goal of making minimally invasive surgery the standard of care in spine.

Gemspring Acquires Zavation Medical Products

Spinal and biologic company Zavation Medical's majority interest was acquired by Gemspring Capital.

Three Questions About the Orthopedic Market in 2Q21

As we near 2Q earnings, we're watching for a barometer of the market's recovery, momentum in M&A as well as the evolution toward digital.

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DJO Acquiring Mathys, Expanding Outside the U.S.

Mathys develops and distributes products for artificial joint replacement, synthetic bone graft solutions and sports medicine applications.

Spectrum Spine Acquires Surface Technology for Spinal Trauma

BIOBraille surface technology is exclusively licensed to Spectrum. It integrates prescriptive laser technology and is designed to improve patient outcomes.

Paragon 28 Acquires Assets of Additive Orthopaedics

The acquisition includes FDA approved, 3D-printed Patient Specific Talus Spacer for the Treatment of Avascular Necrosis for Humanitarian Use.

Shalby Acquires Implant Assets from Consensus Orthopedics

The acquired assets primarily comprise inventory, plant and equipment. Products include knee, mobile bearing knee, hip and revision knee systems.

Kinos Medical Merges with restor3d

Kinos' portfolio mirrors the vision of Restor3d, where pre-operative planning, implant design and intra-op guidance is tailored to the patient and surgeon.

ATEC Marks Tenth Consecutive Quarter of Double-Digit Growth in 1Q21

The company grew 45% in 1Q21 despite surgical volume pressure in January and February as ATEC continues to drive conversion and uptake.

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SeaSpine’s First Quarter Growth Fueled by Volume Gains

The company grew in the mid-teens for 1Q21, driven by new product launches and geographic expansion in the U.S.

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DJO Primed for Growth and Expansion in 2021

The company grew in the high single-digits for 1Q21 and strengthened finances to drive further acquisitions for its foot-and-ankle business.

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Stryker’s Organic Orthopedic Revenue Declines Slightly in 1Q21

While the company's organic revenue declined slightly due to pandemic-related restrictions, its integration of Wright Medical goes smoothly.

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DJO Expands Foot and Ankle Business with MedShape Acquisition

The move is another step in DJO's strategic entry into the estimated $1 billion foot and ankle market that is ripe for consolidation.

Trice Medical Acquires Tenex Health

Tenex Health is a provider of minimally invasive ultrasonic technology for the treatment of chronic pain in soft tissue and bone.

SeaSpine Announces Agreement to Acquire 7D Surgical

The company will purchase all issued and outstanding shares of 7D Surgical for $110 million with a 2Q21 expected close.

Implanet to Acquire Majority Stake in Orthopaedic & Spine Development

Orthopaedic & Spine Development specializes in developing, manufacturing and marketing implants for spine surgery.

Colfax Announces Split into Two Public Companies

Colfax Corporate, owner of DJO, announced today its intention to split into two public companies by the first quarter of 2022.

NuVasive Acquires Simplify Medical

The company announced it acquired Simplify Medical for $150 million in cash along with future regulatory and sales milestones.

Integra Finishes Orthopedics Run with Double-Digit Losses in 2020

The company's orthopedics business declined -13.1% in 2020. Integra closed the divesture of its ortho business to SNN in early 2021.

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DJO Bullish on Reconstruction Business in 2021

Armed with its newly assembled dedicated foot and ankle business, DJO expects double-digit growth in 2021 compared to 2019.

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Zimmer Biomet Spins Off Spine to Focus on More Profitable Businesses

Zimmer Biomet announced it will spin off its spine and dental businesses into a new public company while it focuses on priority markets.

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Neo Medical Acquires TriOs Medical, Expands in Germany and U.S.

Neo is leveraging years of collaboration with TriOs Medical to strengthen its position in the German thoracolumbar fixation market.

Zimmer Biomet Expects First Quarter Declines in 2021, Spins off Spine Business

Despite performing better than many peers in 4Q20 (-1.5%), the company expects more pandemic-related declines in the first quarter of 2021.

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Stryker Closes 2020 with Strong Robot and ASC Performance

The company's Mako robotic system and new customizable ASC plan helped offset losses from COVID-related procedure cancelations.

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DJO Strengthens Foot and Ankle Business with Trilliant Purchase

DJO continued its strategic move into the highly fragmented foot and ankle market with the acquisition of Trilliant Surgical.

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Stryker Strengthens Digital Offerings with OrthoSensor Acquisition

Stryker acquired privately-held OrthoSensor, a leader in sensor technology for total joint replacement to bolster its digital surgery ecosystem.

Collagen Matrix Acquires Resorbable Synthetic Bone Grafts

The transaction includes GUIDOR bone graft substitutes known as easy-graft and calc-i-oss, and builds on the company's strategy to expand its technologies.

Curiteva Acquires 3D Printer, FossiLabs

FossiLabs is the developer of Fused Filament Fabrication 3D-printed PEEK medical implants.

Spinal Elements to Acquire Benvenue Medical Assets

In addition to the Luna XD implant and Orbit discectomy systems, Spinal Elements acquired Benvenue Medical's manufacturing production equipment.

ATEC Renews Agreement to Acquire EOS Imaging

EOS imaging technology offers rapid, low dose, biplanar full-body imaging and 3D modeling capabilities.

Exactech Acquires Muvr, Patient Wearables and Communication Solutions

The latest addition to the Active Intelligence platform, the Muvr portfolio helps surgeons engage with joint replacement patients their care.

3 Orthopedic Acquisitions to Know

In 2020, well-positioned companies made surprising expansions, strategic shifts and small purchases with potential for big impacts.

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Umbra Companies to Acquire Ossifix Orthopedics

All Ossifix pins, screws and plates are single-use surgical kits with all necessary instruments and are based on long-term clinical experience and O.R. use.

DJO Eyes More Acquisitions for Joint Replacement Growth

The company's joint replacement business grew over 9% in 3Q20 as it prepares to enter the high-growth foot and ankle joint replacement market.

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DJO Acquires STAR Ankle and Finger Arthroplasty Systems from Stryker

STAR is one of the first total ankle systems in the market and the Silicone, Surface Replacement and TACTYS finger portfolio holds a leading global market position.

Spine Innovations Spins Out of FH Ortho

Following acquisition of parent company FH Ortho, Spine Innovations is fully independent and dedicated to worldwide sales deployment of ESP disc replacements.

Stryker Completes Wright Medical Acquisition

More than a year after announcing its intention to acquire Wright Medical for $5.4 billion, Stryker today completed the purchase.

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Orthofix Improvement Not Enough to Spur Growth

U.S. spinal sales drove Orthofix's sequential improvement in 3Q20 but were not enough to overcome lingering procedure volume declines due to COVID.

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Zimmer Biomet’s Strategic Transformation Pivots to Active Portfolio Management

The company grew +2.9% in 3Q20 as it begins a new phase of its strategic transformation that includes focus on high growth business lines.

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Stryker Gains Required Regulatory Approvals for Proposed Acquisition of Wright Medical

The U.S. FTC voted to approve the transaction on November 3, and the U.K. Competition and Markets Authority approved the transaction earlier today.

OssDsign to Acquire Sirakoss Bone Graft Substitute Company

OssDsign expects to see revenue from Osteo3 ZP bone graft substitute putty during 2H21 following approval processes in U.S. hospitals.

Olympus Acquires FH ORTHO

The acquisition underscores Olympus' plan to expand orthopedic minimally invasive surgery products, both organically and through mergers and acquisitions.

Integra Returns to Growth on Backlogged Procedures

The company grew its soon to be divested orthopedic franchise +5.1% in 3Q20 as momentum from backlogged procedures carried into the third quarter.

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Colson Medical Announces Merger of Acumed and OsteoMed

Acumed and OsteoMed, both owned by Colson Medical, will gradually integrate over the coming year under the leadership of Acumed CEO Sharon Wolfington.

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Globus Medical Acquires Stake in Synoste from Evonik

Globus Medical acquired all of Evonik's shares in Synoste, a Finnish startup. Synoste's limb-lengthening technology could bolster Globus' trauma business.

DJO Global Emerges as Buyer for Stryker Divestitures

To clear regulatory issues related to its purchase of Wright Medical, Stryker proposed DJO as a buyer for certain ankle and finger joint replacement lines.

Surgalign Announces Agreement to Acquire HoloSurgical

Surgalign Holdings will enter the digital surgery space by acquiring HoloSurgical and it's Augmented Reality and Artificial Intelligence (ARAI) platform.

Integra LifeSciences to Sell Extremity Orthopedics Business to Smith+Nephew

Integra Lifesciences announced a definitive agreement to divest its Extremity Orthopedics business to Smith+Nephew for $240 million.

Royal Biologics Acquires FIBRINET Platelet-Rich Fibrin Matrix

Fibrinet enables safe and rapid preparation of Platelet-Rich Fibrin Membrane and Platelet-Rich Fibrin Gel from a small sample of blood at the point of care.

AK Medical Grows Double-Digits in China

The company grew in the high single digits for 1H20 as it benefited from provincial procurement tenders and the acquisition of Libeier.

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Wenzel Spine Acquires Statera Spine

Statera Spine offers pre-operative diagnostics and quantitative data software to inform treatment decisions for spine patients.

WishBone Medical Acquires Spine Technologies from Back 2 Basics and Orbbo

WishBone acquired assets of Back 2 Basics Direct and Orbbö, companies focused on R&D and commercialization of implants and instruments for spinal fusion.

Amplitude Surgical in Talks for Majority Stake Acquisition

PAI Partners is a European private equity firm. The proposed transaction, subject to regulatory approvals, may complete in 2H20.

Vilex Acquires DT MedTech and Hintermann Total Ankles

The transaction includes the Hintermann H3 3-piece mobile-bearing prosthesis and the Hintermann H2 2-piece, semi-constrained prosthesis.

Medtronic to Acquire Medicrea

Medicrea announced that it entered into an agreement to be acquired by Medtronic at a price of €7 (USD $8.01) per share with a 2020 estimated close date.

Spineart Reaches Definitive Agreement to Acquire Meditech Spine

Spineart has distributed Meditech Spine's products in the U.S. since 2019. This is Spineart's first U.S. acquisition.

Pantheon Surgical Acquires Blue Topaz, CompresSIve Technology

Pantheon Surgical acquired the technology from Osseus Fusion Systems, which will continue to distribute the Blue Topaz/CompresSIve system.

BRICON and PINA Medizintechnik to Merge

The companies' portfolios of cervical and lumbar spinal products are complementary. BRICON is based in Germany and PINA in Switzerland.

Implanet to Divest Madison Total Knee Assets, Focus on Spine

The exclusive negotiations to sell the Madison total knee implant allow the company to focus on growing its spine business.

Safe Orthopaedics to Acquire LCI Medical

Safe Orthopaedics will acquire its contract manufacturing partner to meet growing demand for its implant and instrument kits for spinal surgeries.

M&A Status: Stryker and Wright Medical, RTI Surgical, ATEC

Orthopedic M&A activity is challenged by the COVID-19 environment. We review earlier announced acquisitions and provide thoughts on future activity.

Conventus Orthopaedics to Acquire Flower Orthopedics

This is the next step of Conventus' transformation as it expands distribution channels and builds its portfolio with product development and acquisitions.

HealthpointCapital Acquires Majority Stake in IlluminOss Medical

This investment supports growth of the Photodynamic Bone Stabilization System for minimally invasive intramedullary fixation of bone fractures.

ATEC Terminates Agreement to Acquire EOS imaging

ATEC terminated the agreement to acquire EOS imaging after determining the transaction not feasible due to the negative market impacts of COVID-19.

Spineway Signs Exclusive Contract with MURANAKA Medical Instruments

With this agreement, Spineway can deploy its implants in one of the largest markets in spine and accelerate its sales with higher added value.

Seikagaku Partners with Eisai to Market OA Therapy

Seikagaku and Eisai will co-develop and market knee osteoarthritis treatment SI-613 in China.

OrthoPediatrics to Acquire ApiFix

OrthoPediatrics acquired ApiFix and its minimally invasive deformity correction system, MID-C, for non-fusion treatment of progressive adolescent idiopathic scoliosis.

ATEC to Acquire EOS imaging

Alphatec/ATEC entered into an agreement to acquire EOS imaging for nearly USD $122 million in cash and equity. The transaction is slated to close in 3Q20.

Anika Therapeutics Takes Major Step in Strategic Transformation with Acquisition of Parcus Medical and Arthrosurface

With the acquisitions of Parcus Medical and Arthrosurface, Anika looks ready to complete a major step in its five-year strategic plan to become a leader in joint preservation and restoration.

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Johnson & Johnson to Acquire Remaining Stake in Verb Surgical

Johnson & Johnson, parent to DePuy Synthes Companies, entered into an agreement to acquire the remaining ownership stake in Verb Surgical. The transaction is expected to close in 1H20.

Anika Therapeutics to Acquire Parcus Medical and Arthrosurface

Anika Therapeutics signed agreements to acquire Parcus Medical and Arthrosurface within 1Q20.

Biomatlante Acquired by Advanced Medical Solutions

Advanced Medical Solutions acquired Biomatlante, developer, and manufacturer of orthobiologic products with application in joint reconstruction, spine, trauma, and sports medicine procedures.

Stryker Acquires Wright Medical, Speeds Path to Leadership in Extremities

Stryker acquires Wright Medical for $30.75 per share, total equity value of $4 billion.

Ortho Consulting Group Acquires Osteotec

Ortho Consulting Group Holdings acquired Osteotec, a U.K.-based orthopedic device distributor and manufacturer.

Stryker Completes Acquisition of Mobius Imaging/Cardan Robotics

Stryker completed its acquisition of Mobius Imaging and Cardan Robotics, specialists in point-of-care imaging.

Stryker Enters Definitive Agreement to Acquire Mobius Imaging and Cardan Robotics

Stryker enters definitive agreement to acquire Mobius Imaging and Cardan Robotics for $500MM in cash.

DePuy Synthes Acquiring JointPoint Navigation Assets

DePuy Synthes Products signed a definitive agreement with JointPoint to acquire its navigation software designed for use in hip replacement.

Collagen Matrix Acquired by Private Equity Firm

Collagen Matrix, manufacturer of collagen- and mineral-based products for tissue and bone repair and regeneration, was acquired by Linden Capital Partners.

Carlsmed Merges with Spinal Imaging Company, Precisive Surgical

CARLSMED has merged with Precisive Surgical to provide an end-to-end personalized surgical workflow platform for spine deformity intervention.

Osseus Fusion Systems Acquires SIJ Surgical

Osseus Fusion Systems acquired SIJ Surgical, developer of a sacroiliac fusion screw.

Generex Completes Acquisition of Pantheon Medical – Foot & Ankle

Generex Biotechnology completed its acquisition of Pantheon Medical “ Foot & Ankle, as was announced in 1Q19.

Kuros Biosciences Signs Distribution Agreement with Surgical Specialties for MagnetOs

Kuros Biosciences entered into an agreement whereby Surgical Specialties will distribute MagnetOs synthetic bone graft in Australia and New Zealand.

Celling Spine Acquires Assets of Link Spine

Celling Spine acquired all assets of Link Spine, and will develop spinal fusion hardware to complement its own orthobiologic product portfolio.

Medtronic Completes Acquisition of Titan Spine

Medtronic closed its acquisition of Titan Spine, developer of Endoskeleton® interbody devices and nanoLock® surface technology.

Acumed Acquires System for Scapholunate Ligament Repair

Acumed acquired the RASL System to treat scapholunate ligament injury from Radicle Orthopaedics.

Boston Scientific Closes Vertiflex Acquisition

Boston Scientific closed its previously-announced acquisition of Vertiflex, developer of the Superion® Indirect Decompression System to treat lumbar spinal stenosis.

Smith+Nephew Acquiring Optical Tracking Technology for CAS

Smith & Nephew agreed to acquire Atracsys, provider of optical tracking technology used in computer-assisted surgery.

Bioventus, MTF Biologics Partner on Product Development

Bioventus and MTF Biologics will collaborate to develop a next-generation placental tissue product for the treatment of knee osteoarthritis.

Astura Medical Partners with Academy Medical for DoD/VA Contracts

Astura Medical partnered with Academy Medical for contracting within the U.S. Department of Defense and Veterans Affairs for sales of spinal instrumentation and implants.

OrthoPediatrics Acquires Vilex, ExFix Technology

OrthoPediatrics acquired Vilex, with its Orthex Hexapod circular fixation technology and x-ray planning software, for USD $60MM. Vilex posted 2018 revenue of $11.8MM, mostly derived from U.S. sales.

Smith+Nephew Completes Brainlab Orthopaedic Joint Recon Acquisition

Smith & Nephew completed its previously-announced acquisition of Brainlab's orthopaedic joint reconstruction business.

Exactech Acquires EPIC Extremity, Trauma Device Company

Exactech purchased EPIC Extremity, designer of plates and screws for foot/ankle applications.

DJO Reports March 2019 Revenue of $37.2MM, +17.4% vs. March 2018

DJO posts March 2019 revenue of USD $37.2MM, +17.4% vs. March 2018.

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M&A Recap: Three 2Q Announcements in Spine

Of the 20 OEM-related M&A announcements we've covered in 2019 thus far, seven have related to the spine market. Of those, three were announced in rapid succession within this quarter. Let's see who bought whom, and what they got: Medtronic/Titan Spine, Boston Scientific/Vertiflex and WishBone Medical/CSpine.

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Spineway Making Acquisition in Latin America

Spineway plans to acquire an equity stake in Integral Medical Solutions, a holding company that manages private hospitals in Latin America.

HealthpointCapital Acquires CrossRoads Extremity Majority Stake

HealthpointCapital acquired a controlling stake in CrossRoads Extremity Systems, developer of procedure-specific, sterile-packed implants and instrumentation for foot/ankle fixation.

Medtronic Enters Agreement to Acquire Titan Spine

Medtronic entered into a definitive agreement to acquire Titan Spine, a titanium spine interbody implant and surface technology company.

Boston Scientific to Acquire Vertiflex

Boston Scientific entered into a definitive agreement to acquire Vertiflex, developer of the Superion® Indirect Decompression System. The transaction is slated to close in late 2Q19.

Smith & Nephew Reports 1Q19 Orthopedic Revenue of $879MM, +0.9% vs. 1Q18

Smith & Nephew reports 1Q19 orthopedic revenue of USD $879MM, +0.9% vs. 1Q18.

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WishBone Medical Acquires CSpine

WishBone Medical purchased CSpine, manufacturer of spine and orthopedic implants and instruments.

Axolotl Biologix Acquired by Private Equity Firm

Axolotl Biologix, a developer of regenerative medicine products, was acquired by a private equity firm. The company is preparing for FDA clinical trials of biologic products that have a range of applications in numerous segments, including orthopedics.

OrthoPediatrics/CoorsTek Medical Licensing Partnership

OrthoPediatrics entered into an agreement with CoorsTek Medical for rights to sublicense its Variable-Angle technology.

Smith & Nephew Completes Osiris Acquisition

Smith & Nephew completed its acquisition of Osiris Therapeutics, which was announced in 1Q19.

Bioretec Acquires BRI.Tech and Resorbable Metal Implant Technology

Bioretec acquired BRI.Tech, developer of a novel biocompatible and bioresorbable metal composition.

Acumed Acquires Elbow Arthroplasty Technology

Acumed acquired technology from Bluefish Orthopedics that will support development of a total elbow joint replacement.

Brainlab Acquires Medineering, Robotics Platform

Brainlab has acquired Medineering, a developer of application-specific robotic technologies. The move supports Brainlab's growing market reach into ambulatory surgery centers.

Burst of M&A Activity at the Close of 1Q19

As was shown last week at AAOS, companies are taking strides to connect their devices with technologies that support improved patient outcomes. That connection can come in the form of M&A activity - which certainly applies to transactions announced over the month of March in joint replacement.

CollPlant Renews Arthrex Distribution Agreement for VergenixSTR

CollPlant renewed its exclusive distribution agreement with Arthrex for VergenixSTR for use in soft tissue repair.

Stryker Acquires OrthoSpace

Stryker acquired OrthoSpace, maker of the InSpace device to treat rotator cuff tears, in an all-cash transaction for an upfront payment of US $110MM and future milestone payments of up to an additional $110MM.

Smith & Nephew Acquires Brainlab Joint Replacement Business

Smith & Nephew will acquire Brainlab's orthopedic joint reconstruction business, enabling both companies to accelerate R&D in digital surgery and augmented reality.

Think Surgical, United Orthopedic Collaborate on Total Knees

THINK Surgical and United Orthopedic Corporation will pursue reproducible outcomes in total knee replacements, pairing THINK's Active Robotic System and UNITED's U2 knee.

Geisinger, Medacta Collaborate on Knee Replacement Lifetime Guarantee

Medacta and the Geisinger health system partnered to pilot a knee replacement lifetime guarantee, in which the pair will stand behind the full cost of care associated with surgeries over a patient's lifetime.

Exactech Acquires XpandOrtho

Exactech acquired XpandOrtho, a designer of soft tissue balancing instruments for knee replacement.

Smith & Nephew to Acquire Osiris

Smith & Nephew entered into an agreement to acquire Osiris Therapeutics, developer of regenerative medicine products including skin, bone graft and articular cartilage substitutes. The transaction is expected to close in 2Q19.

RTI Surgical Completes Acquisition of Paradigm Spine

RTI Surgical completed its acquisition of Paradigm Spine, developer of the coflex® Interlaminar Stabilization® device.

Corin Acquiring OMNI, Robot-assisted Total Knee Replacement System

Corin, a U.K. orthopedic company, enters the robotics market by acquiring U.S.-based OMNI.

SeaSpine, Implanet Form US Partnership with Jazz Spinal Devices

Implanet entered into a U.S. private label distribution agreement with SeaSpine covering the Jazz® portfolio of spinal devices.

AxioMed and NanoFUSE Biologics to be Available for Acquisition

KICVentures seeks funding to prepare its portfolio companies, AxioMed and NanoFUSE Biologics, to be acquisition targets.

Trice Medical to Purchase SegWAY Orthopaedics

Trice Medical will acquire SegWAY Orthopaedics, provider of minimally invasive endoscopic systems to treat the extremities.

Orthofix Acquires Distributor, Options Medical

Orthofix Medical acquired Options Medical, a former distributor of OFIX Bone Growth Therapies.

Smith & Nephew Completes Ceterix Acquisition

Smith & Nephew closed its acquisition of Ceterix Orthopaedics.

Kyocera to Expand U.S. Business with Purchase of Renovis Surgical Technologies Assets

Japanese manufacturer Kyocera acquired certain assets of U.S.-based Renovis Surgical Technologies, a manufacturer of 3D-printed implants.

SpineSource Acquires Implant Systems from Kisco

SpineSource acquired the IP assets of two spinal implant systems from Kisco International, including the L-VARLOCK® expandable lumbar cage.

Pantheon Medical Foot & Ankle, Medisource to be Acquired

Generex Biotechnology entered into letters of intent to acquire Pantheon Medical “ Foot & Ankle, manufacturer of the FDA-cleared Balanced Plating System, and distributor Medisource Partners.

Integra Enters Agreement to Develop a Short Stem and Stemless Shoulder System

Integra LifeSciences entered into a license and development agreement with Consortium of Focused Orthopedists for a short stem and stemless shoulder.

LimaCorporate and HSS Founding Hospital-Based 3D Printing Facility

LimaCorporate and the Hospital for Special Surgery are co-founding an additive manufacturing 3D printing facility to create custom orthopaedic implants in a hospital setting.

Medtronic Completes Acquisition of Mazor Robotics

Medtronic completed its planned acquisition of Mazor Robotics in a transaction valued at US $1.7BB.

Smith & Nephew Acquiring Ceterix, Meniscal Repair Technology

Smith & Nephew entered into an agreement to acquire Ceterix Orthopaedics, developer of NovoStitch®Pro Meniscal Repair, for up to US $105MM. The transaction is expected to close in early 2019.

WishBone Medical Granted License for Guided Growth Plate

WishBone Medical was granted a global, non-exclusive license for sale of a guided growth plating system to treat pediatric deformed limbs. Product launch is slated for 1Q19.

WishBone Medical Acquires Response Ortho

WishBone Medical acquired Response Ortho, a manufacturer of external and internal fixation and deformity correction products for the pediatric orthopaedic market.

ChoiceSpine Acquired by Altus Capital

ChoiceSpine, a manufacturer of devices and biologics used to treat complex spine disorders, was acquired by Altus Capital Partners.

DJO Global to be Acquired by Colfax for $3.15BB in Cash

Colfax entered into a definitive agreement to acquire DJO Global from Blackstone for US $3.15BB in cash. The transaction is expected to close in 1Q19.

Innovasis Signs Private-Label Agreement with Stability Biologics

Innovasis entered into a private-label agreement with Stability Biologics that includes access to Physio® bone allograft. Product launch is expected by year-end.

Medacta Acquires Balgrist CARD

Medacta invests in personalized medicine by acquiring startup Balgrist CARD.

Implanet Enters Distribution Agreement with KICO Knee

Implanet partnered with KICO Knee Innovation Company for distribution of the MADISON primary total knee.

Arthrex Collaborates with CellRight Technologies on Distribution

CellRight Technologies, a Tissue Regenix company, entered into an agreement granting Arthrex distribution rights to its BioRinse bone portfolio in Europe.

Stryker Completes K2M Acquisition

Stryker closed the previously-announced $1.4BB acquisition of K2M.

WishBone Medical Acquires Red Star Contract Manufacturing

WishBone Medical acquired Red Star, a contract manufacturer, to provide sterile packaging and plastic injection molded single-use instruments for the pediatric orthopaedic market.

RTI Surgical Acquiring Paradigm Spine

RTI Surgical entered into a definitive agreement to acquire Paradigm Spine in a cash and stock transaction valued at up to US $300MM.

Stryker Completes Invuity Acquisition

Stryker completed its previously-announced acquisition of Invuity, manufacturer of single-use, lighted visualization instruments.

Contract Manufacturer M&A: 2017-3Q18

Merger and acquisition activity is shaping the broader orthopedic supply chain base, with contract manufacturers of all sizes transforming in the last decade to keep pace with their scaling device company customers. We've identified three M&A trends in this portion of the market.

DePuy Synthes to Co-Promote Ortho Development’s KASM Spacer in the U.S.

DePuy Synthes entered into an exclusive U.S. co-promotion agreement with Ortho Development for the KASM® Knee Articulating Spacer Mold.

Wright Medical Completes Cartiva Acquisition

Wright Medical completed its acquisition of Cartiva, developer of the Synthetic Cartilage Implant.

NuVasive Awarded Neuromonitoring Services Contract with Premier

NuVasive Clinical Services was awarded a three-year, sole source supplier contract for Intraoperative Neuromonitoring with Premier, effective November 2018.

NuVasive Enters Partnership with Biedermann Technologies

NuVasive entered into a strategic partnership with Biedermann Technologies to integrate proprietary screw technology into NUVA's RELINE® portfolio, for 1H19 launch.

Corin Acquiring Global Orthopaedic Technology

Corin signed a binding agreement to acquire Global Orthopaedic Technology, manufacturer of hip and knee replacement devices in Australia.

Amedica Closes Sale of Spine Portfolio to CTL Medical

Amedica completed the sale of its spine business to CTL Medical, which is now exclusive owner of the metal and silicon nitride spine product portfolio.

Bioventus Signs Pfizer as Exclusive DUROLANE Distributor in Brazil

Bioventus received ANVISA approval to market DUROLANE® single-injection in Brazil to treat hip osteoarthritis. Pfizer will serve as its exclusive distribution partner.

4WEB Partners with Tedan, Lattus on Total Lateral Solution

4WEB Medical entered into an exclusive partnership with Lattus Spine and TeDan Surgical Innovations to co-market a turnkey Total Lateral Solution, with retractor and implant.

Medtronic to Acquire Mazor Robotics

Medtronic entered into a definitive agreement to acquire Mazor Robotics for US $1.64BB in cash in a transaction that is slated to close in January 2019.

Spine Company M&A Picks Up in 3Q18

We've tracked 31 mergers and acquisitions in the spine space from 2017 through mid-September 2018...with eight of them happening in just the last four weeks. The global spine market comprises nearly 300 companies; players need broad portfolios or novel technologies to vie for market share today.

Zavation Acquires Pan Medical U.S. Corp.

Zavation acquired PanMed, a manufacturer of minimally invasive products used in the kyphoplasty and interventional radiology markets.

Globus Medical Acquires Nemaris, Surgimap Software

Globus Medical is acquiring Nemaris, developer of Surgimap® software used to preoperatively plan spine surgery. Terms were not disclosed.

IZI Medical Products Acquires Benvenue Medical’s Vertebral Augmentation Systems

IZI Medical is acquiring Benvenue Medical's vertebral augmentation systems portfolio, used for treatment of spinal fractures.

JNJ Acquires Emerging Implant Technologies

Johnson & Johnson Medical Devices is acquiring Emerging Implant Technologies, a manufacturer of 3D-printed titanium interbodies for spinal fusion.

Stryker Acquires Instrument Manufacturer Invuity

Stryker entered into a definitive agreement to acquire instrument manufacturer Invuity for US $190MM in equity. The transaction is slated to close in 4Q18.

LimaCorporate Acquiring TechMah Medical to Expand Digital Solutions

LimaCorporate is acquiring medical device software company TechMah Medical to complement its joint reconstruction implants with digital applications.

Amedica to Divest Spine Business to CTL Medical

CTL Medical will acquire the commercial spine business of Amedica for US $10.0MM. The transaction is slated to close within 3Q18.

Stryker Acquiring K2M

Stryker entered into a definitive merger agreement to acquire K2M for ~US $1.4BB in cash. The transaction is slated to close in 4Q18. For 2017, K2M posted revenue of $249.3MM, +8.8% vs. 2016.

Wright Medical Acquiring Cartiva

Wright Medical is acquiring Cartiva, a manufacturer of the Synthetic Cartilage Implant to treat arthritis in the great toe, for US $435MM. The transaction is expected to close in 4Q18.

Viscogliosi Bros. Acquiring OP-1 Portfolio

Ember Therapeutics plans to divest its OP-1 bone morphogenetic protein (BMP-7) portfolio to Viscogliosi Brothers. The transaction is slated to close by 4Q18.

KFx Medical Enters License with Zimmer Biomet

KFx Medical entered into a license agreement with Zimmer Biomet to promote products and techniques for knotless double row rotator cuff repair.

NuVasive and Siemens Healthineers Partner on Surgical Automation Tools

NuVasive and Siemens Healthineers entered into a Spine Precision Partnership to integrate the Pulse surgical automation platform with Siemens' Cios Spin mobile 3D C-arm.

Fuse Medical Acquires Maxim Surgical

Fuse Medical acquired Maxim Surgical, a manufacturer of spinal fusion devices.

RTI and Aziyo Partner on ViBone Cellular Matrix

RTI Surgical and Aziyo Biologics signed an agreement for RTI's exclusive U.S. distribution of ViBone® cellular bone matrix.

BONESUPPORT Signs Strategic Agreement with MTF Biologics

BONESUPPORT entered into an agreement with MTF Biologics, gaining U.S. rights to distribute two demineralized bone matrices.

Bioventus to Divest BMP Development to Viscogliosi Brothers

Bioventus entered into a definitive agreement to divest its next-gen bone morphogenetic protein development program to Viscogliosi Brothers. The transaction is slated to close in 3Q18.

Aziyo Partners with SurGenTec for Minimally Invasive Bone Graft Delivery

Aziyo Biologics entered into an agreement to supply ViBone viable bone matrix for distribution with SurGenTec's GraftGun delivery system.

Onkos Surgical and Insight Medical to Study Augmented Reality in Musculoskeletal Oncology

Insight Medical Systems and Onkos Surgical are entering a pilot project to explore use of the ARVIS augmented reality system in bone tumor surgery.

Medigus Enters Orthopaedic Market, Partners with AM Surgical

Medigus entered into a development agreement with A.M. Surgical to develop an integrated visualization device to complement Stratos, A.M. Surgical's product for endoscopic carpal tunnel release.

Safe Orthopaedics Enters Distribution Agreement with KiSCO for Japan

Safe Orthopaedics entered into an exclusive commercialization and distribution agreement in Japan with KiSCO.

CoreLink Acquiring Expanding Orthopedics

CoreLink has acquired Expanding Orthopedics, developer of the FLXfit line of expanding interbody devices. Terms were not disclosed.

Safe Orthopaedics Acquires UK Distributor Qspine

Safe Orthopaedics will acquire the salesforce of U.K. distributor Qspine.

BONESUPPORT Signs Strategic U.S. Agreement with Collagen Matrix

BONESUPPORT entered into an agreement with Collagen Matrix on U.S. sales of bone graft substitute products through its own U.S. distribution network, beginning in 4Q18.

In’Tech Medical to Acquire Bradshaw Medical

In™Tech Medical, a contract manufacturer for the orthopaedic industry, entered into a binding agreement to acquire Bradshaw Medical.

DePuy Synthes Acquiring ME1000 Surgical Impactor

DePuy Synthes signed a definitive agreement to acquire the assets of Medical Enterprises Distribution, developer of the ME1000 Surgical Impactor for use in hip replacement. The transaction is slated to close in 2Q18.

Corin to be Acquired by Permira

Corin is to be acquired by a company backed by investment firm Permira for an undisclosed sum, in a transaction slated to close in early 3Q18.

DePuy Synthes, Prosidyan Partner on FIBERGRAFT Products

DePuy Synthes entered into an exclusive agreement to promote Prosidyan's FIBERGRAFT® synthetic bone graft in spinal fusion, starting in 2Q18.

Integer to Divest Advanced Surgical and Orthopedics to MedPlast

Integer entered into an agreement to sell its Advanced Surgical and Orthopedics lines to MedPlast, a global services provider to the medical device industry, for US $600MM in cash. The transaction is expected to close in 3Q18.

Cadence to be Acquired by Kohlberg Private Equity Firm

Cadence, global provider of high-precision components and finished devices for orthopaedic and other markets, signed a definitive agreement to be acquired by private equity firm Kohlberg & Company.

JRI Orthopaedics Acquired by AK Medical

JRI Orthopaedics, manufacturer of hip and shoulder reconstruction devices, was acquired by AK Medical for £16.7MM (~US $23.7MM).

HydroCision and Konica Minolta Partner on Tendinopathy Treatment

Konica Minolta will distribute HydroCision's TenJet Percutaneous Tenotomy system to manage diseased tendon tissue under ultrasound.

NN, Inc. Acquiring Paragon Medical

NN entered into a definitive agreement to acquire Paragon Medical for US $375MM in cash. For 2017, Paragon posted revenue of $141.0MM. The transaction is slated to close during 2Q18.

KFx Medical Enters License with Wright Medical

KFx Medical entered into a license agreement allowing Wright Medical Technology to promote products and techniques for knotless double row rotator cuff repair, as claimed in U.S. Patent No. 7,585,311.

Orthofix Enters Agreement to Acquire Spinal Kinetics

Orthofix entered into a definitive agreement to acquire Spinal Kinetics for US $45MM in cash plus up to $60MM in potential milestone payments. The transaction is expected to close in 2Q18.

Alphatec Spine Acquires SafeOp, Provider of Neuromonitoring Tech

Alphatec Spine acquired SafeOp Surgical, provider of neuromonitoring technology, for an initial outlay of US $15MM, and also announced new leadership appointments.

WishBone Medical Collaborates with HSS for Pediatric Total Hip

WishBone Medical entered into a license agreement with the Hospital for Special Surgery to develop a Pediatric Total Hip.

Onkos Surgical, 3D Systems Partner for Surgical Oncology Tools

Onkos Surgical signed a 4-year agreement with 3D Systems to develop and advance patient-specific tools for use in tumor-related reconstruction in the pelvis and long bones.

CellRight Enters Distribution Agreement with Arthrex

CellRight Technologies signed a long-term, multi-year distribution agreement with Arthrex for CellRight's orthobiologic products for use in orthopaedic, spine and foot/ankle procedures.

WishBone Medical to Distribute Implanet’s JAZZ Implants

WishBone Medical entered into a U.S. distribution agreement with Implanet addressing JAZZ spinal implants.

Leader Biomedical Acquires International Orthopaedics

Leader Biomedical is acquiring International Orthopaedics, manufacturer of ICON total hip and hip resurfacing implants and instruments.

Implanet and L&K Biomed Finalize Cross-Distribution Agreements

Implanet and L&K Biomed finalized agreements for cross-distribution of spinal products in the U.S., Asia/Oceania and Europe.

Bioventus and LifeLink Collaborate on Bone Allograft

Bioventus and LifeLink Tissue Bank will co-develop bone allograft for spine and trauma applications.

JNJ Collaborating with Trinity College Dublin on 3D Bioprinting Lab

Johnson & Johnson will collaborate with Trinity College Dublin to open a 3D bioprinting research lab, initially focusing on orthopaedic-related projects.

JNJ Acquires Orthotaxy Robotic-Assisted Technology for Knee Surgery

Johnson & Johnson Medical Devices is acquiring Orthotaxy, developer of a robotic-assisted surgery solution in early-stage development for total and partial knee replacement.

Bioventus/Seikagaku Extend SUPARTZ FX Distribution Agreement

Bioventus extended its agreement to exclusively distribute Seikagaku's SUPARTZ FX five-injection hyaluronic acid in the U.S. through May 2028.

Implanet Enters Distribution Agreement with Aegis Spine

Implanet entered into a U.S. distribution agreement with Aegis Spine, subsidiary of L&K Biomed, to complement Implanet's commercialization activity in the region.

AANA and VirtaMed to Partner on Virtual Reality Simulation

The Arthroscopy Association of North America and VirtaMed signed an agreement to co-develop virtual reality arthroscopy simulation training.

RTI Surgical Acquiring Zyga Technology

RTI Surgical entered into an agreement to acquire Zyga Technology, developer of the SImmetry® Sacroiliac Joint Fusion system.

Histogenics and MEDINET Sign Agreement for NeoCart in Japan

Histogenics entered into an agreement with MEDINET to develop and commercialize NeoCart® cartilage repair therapy in Japan.

Vericel Receives First Payment from Innovative Cellular Collaboration

Vericel initiated its Carticel/MACI distribution agreement with Innovative Cellular Therapeutics following a US $5.1MM upfront payment.

Centinel Spine Completes prodisc Acquisition

Centinel Spine completed the acquisition of worldwide prodisc® total disc replacement assets from DePuy Synthes Products.

Wright Medical Acquires BLUEPRINT Partner, IMASCAP

Wright Medical acquired IMASCAP, developer of the technology that drives BLUEPRINT™ 3D surgical planning software, for US $88.8MM in cash, stock and milestone payments.

Bodycad Enters EU Distribution Agreement with OrthoGrow

Bodycad entered into an exclusive agreement with OrthoGrow for distribution of its unicompartmental knee in the European Union.

NuVasive Acquiring SafePassage Neuromonitoring Company

NuVasive entered into a definitive agreement to acquire SafePassage, provider of intra-op neurophysiological monitoring services. The company will join NUVA's Clinical Services business in a transaction slated to close in January 2018.

Smith & Nephew Completes Rotation Medical Acquisition

Smith & Nephew completed its acquisition of Rotation Medical, developer of novel tissue regeneration technology for shoulder rotator cuff repair.

curasan Enters Distribution Agreement with Implantcast

curasan entered into an exclusive agreement with Implantcast for distribution of CERASORB bone regeneration products in Austria, Germany and Switzerland.

OrthoPediatrics to Distribute Bioretec Devices under Private Label

OrthoPediatrics will market Bioretec's bioresorbable bone and soft tissue fixation implants under its own TorqLoc™ brand.

Xtant Medical and curasan Enter Distribution Agreement

Xtant Medical entered the U.S. bone graft substitute market through a distribution agreement with curasan.

Arthrosurface Acquires Acellular Dermal Technology for Ortho Applications

Arthrosurface acquired IP from WASAS pertaining to an acellular dermal stabilization allograft device that may address various orthopaedic therapeutic challenges.

K2M, Brainlab to Collaborate on Spinal Navigation

K2M and Brainlab will partner to commercialize and co-market future navigated K2M spinal systems for open and MIS procedures.

Stryker Acquiring Vexim and SpineJack VCF Implant

Stryker acquired Vexim, developer of the SpineJack® expandable vertebral compression fracture implant, for ~US $191.0MM. The transaction is expected to close in 4Q17.

Sites Medical and Integrity Implants Enter License Agreement

Sites Medical entered into an agreement to license OsteoSync™ Ti technology to Integrity Implants for its use in expandable interbody devices.

In’Tech Medical Acquires Pyxidis

In'Tech Medical acquired Pyxidis, a manufacturer of customized metal and plastic sterilization cases and trays for surgical Instruments.

K2M Acquires Cervical VBR from Cardinal Spine

K2M acquired Cardinal Spine's cervical static corpectomy cage, to be branded as the PALO ALTO® system.

Smith & Nephew to Acquire Rotation Medical

Smith & Nephew entered into a definitive agreement to acquire Rotation Medical for US $125MM in initial cash. The transaction is expected to close by year-end.

Corin Acquires Large Joint Unit of Distributor MBA

Corin acquired the large joint business unit of its distributor, MBA Belgium & Luxembourg.

Orthobiologics Activity Signals Collaborations and Clinical Data Essential for Company Growth

ORTHOWORLD estimates that global orthobiologic product sales account for ~10% of the orthopaedic market's revenue, overall. In 2016, that translated to just over $4.9 billion, an increase of 3% vs. 2015. For 2017 and into 2019, we're projecting similar growth.

NN, Inc. Acquires DRT Medical

NN, Inc. acquired DRT Medical, supplier of precision manufactured orthopaedic implants and instruments. Financial terms were not disclosed.

Bone Therapeutics and Asahi Kasei Sign Exclusive License Agreement for PREOB

Bone Therapeutics signed an exclusive license agreement with Asahi Kasei to develop and commercialize PREOB® autologous bone cell therapy.

Centinel Spine to Acquire DePuy Synthes prodisc Assets

Centinel Spine entered into an agreement to purchase DePuy Synthes' worldwide prodisc artificial disc assets.

Artoss Enters DAPA Agreement for NanoBone Graft Products

Artoss entered into a Defense Acquisition Purchasing Agreement with Owens & Minor for U.S. Department of Defense access to NanoBone bone graft.

NuVasive Acquires Vertera Spine

NuVasive acquired Vertera Spine, developer of porous-PEEK-based spinal interbody fusion devices. Transaction terms were not disclosed.

ApiFix Signs Canada Distribution Agreement

ApiFix granted exclusive distribution rights to Joint Solutions Alliance for its scoliosis treatment in Canada.

Mazor Robotics and Medtronic Enter Next Phase of Strategic Partnership

Mazor Robotics entered Phase II of its strategic partnership with Medtronic, which will now take on exclusive global distribution of the Mazor X surgical assistance platform.

OrthoPediatrics and Mighty Oak Medical Partner on Spinal Navigation

OrthoPediatrics entered into an agreement for exclusive U.S. distribution of Mighty Oak Medical's FIREFLY® pedicle screw navigation guides in pediatric hospitals.

Orthopaedic Supplier M&A Boosted by Private Equity Backing

Supplier companies have been involved in 17 of the 33 mergers and acquisitions that have closed in the orthopaedic space as of August 15, according to our tracking of activity. This activity comes in direct response to device company consolidation.

DePuy Synthes and JointPoint to Co-market Hip Replacement Navigation System

DePuy Synthes entered into an exclusive U.S. agreement with JointPoint to co-market a surgical navigation platform for total hip replacement, beginning in 2H17.

Bone Biologics Expands Relationship with UCLA

Bone Biologics entered into an exclusive license agreement with UCLA for global application of NELL-1 protein in the treatment of osteoporosis and trauma, through a technology transfer.

ConforMIS Acquires Machining, Polishing Assets from Broad Peak Manufacturing

ConforMIS acquired the machining and polishing assets of its supplier, Broad Peak Manufacturing, for US $6.5MM.

DePuy Synthes to Co-market Surgical Impactor for Total Hip Arthroplasty

DePuy Synthes gained exclusive rights to co-market Medical Enterprises' ME1000™ Surgical Impactor for use in Total Hip Arthroplasty.

Globus Medical Acquires KB Medical, Robotics Developer

During 2Q17, Globus Medical acquired KB Medical, Switzerland-based developer of the AQrate™ Robotic Assistance system.

K2M Acquires Expandable Interbody IP Portfolio

K2M acquired exclusive license to a portfolio of 17 issued and pending patents for expandable interbody technology.

SpineSource Awarded DOD Contract for L-Varlock Expandable Cage

SpineSource was awarded a contract to supply the U.S. Department of Defense with the L-Varlock® expandable lumbar cage.

OrthAlign Enters Distribution Partnership in Panama

OrthAlign announced first KneeAlign® total knee arthroplasties completed in Panama, alongside entrance into a distribution partnership with Ortosistemas.

OsteoRemedies, Adhezion Biomedical Enter Distribution Agreement

Adhezion Biomedical entered into an exclusive U.S. distribution agreement with OsteoRemedies for FLORASEAL® Microbial Sealant.

Tissue Regenix Proposes Acquisition of CellRight Technologies

Tissue Regenix proposes to acquire CellRight Technologies for US $30MM, to offer products for bone and soft tissue regeneration.

ApiFix Enters Spain Distribution Agreement with Acuna-Fombona

ApiFix entered into an exclusive distribution agreement with Acuna-Fombona to market the ApiFix scoliosis system in Spain.

CTL Medical to Market G-21 Products in US

CTL Medical entered into an agreement to market G-21's bone cement, kyphoplasty and vertebroplasty products in the U.S.

K2M Enters Distribution Agreement with Japan Medicalnext

K2M signed a long-term exclusive distribution agreement with Japan Medicalnext.

Ortho Development Signs Agreement for China Distribution of Balanced Knee

Ortho Development granted China Pioneer Pharma exclusive regional distribution rights for the Balanced Knee® system.

MedShape Divests ACL Fixation Products to ConMed

MedShape reached a definitive agreement for ConMed to acquire the ExoShape® ACL fixation system.

DePuy Synthes Acquires Sentio to Expand Reach in Minimally Invasive Spine Market

DePuy Synthes acquires Sentio and its nerve localization technology for minimally invasive spine surgery.

SpineGuard and XinRong Medical Enter Distribution Agreement For PediGuard in China

SpineGuard entered an exclusive distribution agreement with XinRong Medical for PediGuard® in China, Hong Kong and Macau.

GE Additive and Stryker Enter Additive Manufacturing Partnership

GE Additive and Stryker established an agreement to support Stryker's growth in additive manufacturing, covering new machines, materials and services.

Cretex Companies Acquires Quality Tech Services, Supplier of Outsourced Packaging

Cretex Companies acquired Quality Tech Services, supplier of outsourced packaging for the medical device industry.

Premier to Offer Bioventus Surgical Orthobiologics Products to Members

Premier is now offering Bioventus' full surgical orthobiologics product portfolio to its U.S. membership, comprising 3,750 hospitals and >130,000 provider organizations.

Polyaxial ZIP ISP Technology Available for Out-Licensing

Aurora Spine's proprietary implant locking technology is available for out-licensing or private labeling opportunities.

LITHOMED to Distribute SANUWAVE Orthopaedic Products in Taiwan

SANUWAVE Health appointed LITHOMED to distribute the orthoPACE® shockwave therapy device in Taiwan.

Integra LifeSciences to Distribute aap Implantate’s LOQTEQ Distal Radius System

Integra LifeSciences signed an agreement with aap Implantate to distribute the LOQTEQ® Distal Radius System in the U.S.

Vericel Signs Distribution Agreement with Orsini Pharmaceutical

Vericel entered into a 2-year renewable agreement with Orsini Pharmaceutical for distribution of Carticel® and MACI® in the U.S. and Puerto Rico.

Zimmer Biomet Licenses IP from Bonutti Research

Zimmer Biomet entered into an agreement to license patents from Bonutti Research, supporting the development of the Rosa® robotic total knee application.

Stryker to Distribute AlloSource Products for Sports Medicine Procedures

Stryker entered into an agreement to distribute AlloSource biologic products in the U.S. for use in sports medicine procedures.

Seikagaku Enters Collaboration on SI-613 in Japan

Seikagaku entered into a basic co-development and marketing collaboration with Ono Pharmaceutical in Japan for SI-613 for the treatment of osteoarthritis.

Xtant Medical to License Sites Medical OsteoSync Ti Technology

Xtant Medical (XTNT) entered into a licensing agreement with Sites Medical for use of OsteoSync™ Ti porous titanium scaffold technology with XTNT's spinal products.

DePuy Synthes Awarded US DOD Contract for Orthopaedic Products

DePuy Synthes was awarded a contract from the U.S. Department of Defense to supply up to US $260MM worth of orthopaedic products to global U.S. military medical facilities.

Vericel Licenses Products for Distribution in Southeast Asia

Vericel entered into a license agreement whereby Innovative Cellular Therapeutics will obtain exclusive rights to develop and distribute Carticel® and MACI® in Southeast Asia.

Cook Medical Divests Vertebroplasty Products

Cook Medical sold its vertebroplasty product line to IZI Medical Products.

Medikon to Distribute InterFuse in Turkey

Vertebral Technologies partnered with Medikon for distribution of InterFuse® spinal fusion products in Turkey.

Tecomet Purchased by Charlesbank Capital Partners

Genstar Capital sold Tecomet, a global supplier of high-precision manufacturing solutions for orthopaedic implants, instruments and sterilization cases/trays, to Charlesbank Capital Partners.

Titan Metal Fabricators Closes Acquisition of Edge International

TITAN Metal Fabricators acquired select assets of Edge International, distributor of raw materials used in the manufacture of implants and instruments for the orthopaedic, spine and trauma markets.

aap Enters US Distribution Agreement for LOQTEQ Radius System

aap Implantate entered into a distribution agreement for the LOQTEQ® Radius System with an unnamed, U.S.-based global medical technology company.

7D Surgical Gains US Distribution for Spinal Image Guidance System

7D Surgical entered into exclusive partnerships with Surgical One and DB Surgical for U.S. distribution of its Machine-Vision Image Guided Surgery platform for spine procedures.

DePuy Synthes Acquires 3D Printing Technologies to Treat Bone Defects

DePuy Synthes acquired 3D printing technology from Tissue Regeneration Systems to offer patient-specific, bioresorbable implants for orthopaedic and CMF applications.

Amendia Acquired Spinal Elements

Amendia acquired Spinal Elements, provider of implants, instruments and orthobiologics. Terms were not disclosed.

United Orthopedic Acquires A-Spine, Expanding Sales in China

United Orthopedic acquired A-Spine Asia, developer of spinal fixation, osteoplasty and vertebral body replacement systems, for US $20.0MM. For 2016, A-Spine posted revenue of $11.3MM.

Audax Medical Licenses Novel Self-Assembling Nanomolecule

Audax Medical was granted an exclusive worldwide license from Northeastern University for a self-assembling, arginine-rich nanomolecule for development in tissue regeneration.

DJO Global Partners with IPG

DJO Global's Surgical Division partnered with IPG on delivery of its products to IPG's health plan clients and patients.

KFx Medical Enters Agreement with ConMed

KFx Medical entered into a license agreement with ConMed addressing patents used in knotless double row rotator cuff repair.

K2M and LifeHealthcare Distribution Agreement

K2M and LifeHealthcare entered into a new 5-year distribution agreement for K2M's spinal technologies in Australia and New Zealand.

License Agreement for OMNI’s APEX Knee

OMNIlife science signed an agreement granting exclusive license to Global Orthopaedic Technology to manufacture and market the APEX™ Knee in Australia, New Zealand and South Africa.

Medovex Gains Distribution Partner in Germany

Medovex entered into a distribution partnership with Technology Consult Berlin for its Denervex™ system in Germany.

IBS Investment Bank Acquires Interest in Progressive Orthopaedics

IBS Investment Bank acquired a minority membership interest in The Progressive Orthopaedic Company.

Organogenesis Acquiring NuTech Medical

Organogenesis is acquiring NuTech Medical, developer of amniotic products with application in soft tissue and bone regeneration.

Sussex Wire Acquires Marox

Sussex Wire, manufacturer of cold formed components for a variety of industries, acquired Marox, a manufacturer of orthopaedic implants and instruments.

Zimmer Biomet Product Highlights

Zimmer Biomet has publicly unveiled Signature Solutions, and is previewing a concept device that will support personalization and intelligent instrument technology through surgical robotics.

Amend Surgical Enters Agreement with UFRF for Biomimetic Bone Development

Amend Surgical entered into an exclusive agreement with The University of Florida Research Foundation to license patents for the development of Biomimetic Bone.

BONESUPPORT Extends U.S. Distribution Agreement with Zimmer Biomet for CERAMENT

BONESUPPORT extended its U.S. distribution agreement with Zimmer Biomet (ZBH), continuing ZBH's exclusive rights for CERAMENT BONE VOID FILLER.

Implanet Enters Exclusive Distribution Partnerships in Australia and New Zealand

Implanet announced integration of its Jazz Claw device into the Australian Register of Therapeutic Goods and entry into an exclusive partnership with Device Technologies for product distribution in Australia and New Zealand.

Distribution Agreement for BoneScalpel in China

Misonix entered into an exclusive agreement with Weigao Orthopedic for distribution of the BoneScalpel in China, Hong Kong and Macau.

Three New Ex-U.S. Distribution Partners for VTI

Vertebral Technologies appointed new distributors in Finland, Germany and Sweden to expand access to InterFuse® modular interbody fusion implants.

Shoulder Options Seeks to Divest Proximal Humerus Plates

Shoulder Options seeks to divest its AFT™ Proximal Humerus Fracture, AFT Greater Tuberosity Fracture and CRP™ Cuff Repair plates.

Wenzel Spine Acquires PrimaLOK SP & FF Platforms from OsteoMed

Wenzel Spine acquired PrimaLOK™ SP Interspinous Fusion and PrimaLOK™ FF Facet Fixation systems from OsteoMed.

The Forgotten Phase of M&A: Post-Close Supply Chain Integration

Proper implementation post-acquisition-close will allow your supply chain to deliver immediate and long-term value, and avoid integration delays and disruptions.

Hospital M&A, Priorities Offer OEMs Strategic Direction

The U.S. hospital landscape steadily continues to be shaped by consolidation that is forced by competition, declining reimbursement and public and private payor cost and control measures. As these trends are expected to endure at least through the next decade, it's imperative that you understand what your hospital customer base will look like several years from now.

Medacta Acquires Austrian Distributor, Vivamed

Medacta acquired Vivamed, its Austrian distributor of 15 years.

Vertebral Technologies Enters GPO Contract

Vertebral Technologies entered into a GPO contract to provide modular interbody fusion devices to member facilities of Resource Optimization & Innovation/ROi.

Trice Medical Partners with Pacific Medical

Trice Medical entered into an agreement with Pacific Medical for multi-state distribution of the mi-eye 2™ in-office arthroscopic diagnostic tool in the U.S.

SpineSource to Market Kisco’s L-Varlock Expandable Lumbar Cage

SpineSource entered into a long-term exclusive U.S. agreement to distribute Kisco International's L-Varlock® Expandable Lumbar Cage for vertebral interbody fusion.

Exactech Divests Assets to ChoiceSpine

Exactech has restructured its Spine & Biologics segment, divested its spine product assets to ChoiceSpine and announced restructuring charges related to ex-U.S. operations. Terms were not disclosed.

OsteoMed Acquires OT Medical’s InstaFix Shape Memory Staple

OsteoMed completed the acquisition of OT Medical's InstaFix™ shape memory staple systems.

DePuy Synthes Agreement with Pacira Pharmaceuticals

DePuy Synthes entered into an exclusive agreement with Pacira Pharmaceuticals for U.S. co-promotion of EXPAREL® local analgesic across its joint reconstruction, spine, sports medicine and trauma businesses.

The Forgotten Phase of M&A: Mitigating Supply Chain Risks

The primary responsibility of the supply chain team post-M&A is the assurance of uninterrupted upstream and downstream product supply. These essential steps will assist you in identifying supply chain risk and developing a plan to minimize that risk.

Bovie Medical Enters Sales Partnership with ConMed

Bovie Medical entered into a global sales channel partnership agreement with CONMED for its PlazXact™ Ablator, which will be marketed as the UltrAblator Bipolar® series effective in late 1Q17.

New Durolane Agreement in Russia

Bioventus selected MEDSERVICE to distribute DUROLANE® single-injection joint fluid in Russia.

Orthocell Collaborates with Johnson & Johnson Innovation

Orthocell entered into a research collaboration agreement with DePuy Synthes Products for the Ortho-ATI® stem cell treatment for tendon and ligament regeneration.

OssDsign Secures New EU Distribution Partnerships

OssDsign entered into new commercial partnerships covering distribution of its products for cranial repair and facial bone reconstruction in Italy, Spain, Switzerland, Austria and The Netherlands.

Medovex Enters International Distribution Agreement with AlfaMed

Medovex entered into an international distribution agreement with AlfaMed for distribution of its DenerveX™ System throughout Italy.

DePuy Synthes Acquires Interventional Spine Expandable Cage Technology

DePuy Synthes entered into an asset purchase and development agreement with Interventional Spine, addressing expandable fusion cages and a facet screw system for open and percutaneous spine surgery.

AxioMed/DSM Extend Terms on Exclusive License Agreement

AxioMed modified terms of a previously-signed 15-year exclusive license agreement with DSM Biomedical, holder of the patent on polymer technology used in AxioMed's viscoelastic disc replacement.

aap Implantate’s New U.S. Distribution Contract for LOQTEQ Products

aap Implantate entered into a distribution contract for LOQTEQ® trauma products with an unnamed U.S. healthcare service provider.

New DUROLANE Agreement

Bioventus entered into an agreement with Galderma to bring DUROLANE knee osteoarthritis treatment to the U.S.

Amplitude Surgical Acquires 50% Stake in SOFAB Orthopedie

Amplitude Surgical acquired a 50% stake in industrial subcontractor SOFAB Orthopedie.

GE Concludes Offers for Concept Laser, Arcam

GE completed its agreements to acquire stakes in Arcam and Concept Laser.

OrthoMend Acquires License to Absorbable Bone Fixation, Repair Technologies

OrthoMend Research acquired from Temple University researchers an exclusive license to develop novel absorbable bone fixation and regenerative repair technologies for commercial use.

MedPlast Acquired by Strategic Investor, PE Firm

MedPlast, parent company of OrthoPlastics, was acquired by strategic investor Water Street Healthcare and JLL Partners, a middle-market private equity firm. Terms were not disclosed.

Cerapedics Awarded Group Purchasing Contract with Premier

Cerapedics was awarded a group purchasing agreement with Premier addressing i-FACTOR™ Peptide Enhanced Bone Graft.

HD Surgical Acquires Assets from PAK Manufacturing

HD Surgical, a custom orthopaedic surgical instrument and implant manufacturer, recently acquired certain assets of PAK Manufacturing, a maker of custom and specialty handheld surgical instruments.

Konica Minolta and Mindray to Develop Musculoskeletal Ultrasound Products

Konica Minolta Healthcare partnered with Mindray to develop portable musculoskeletal ultrasound devices.

GE to Acquire Stake in Concept Laser

General Electric reached an agreement to acquire a 75% stake in Concept Laser, manufacturer of powder bed-based laser additive manufacturing machines, for 549MM (~US $599MM).

Zimmer Biomet Acquires RespondWell Telerehabilitation Platform for Signature Solutions

Zimmer Biomet acquired RespondWell® telerehabilitation technology, designed to provide personalized, clinician-supervised post-surgical physical therapy in a patient's home.

NuVasive Expands iGA Platform to Support Cervical Alignment

NuVasive is introducing an Integrated Global Alignment™ platform that is expanded to support cervical alignment. Further, the company acquired LessRay software technology from SafeRay Spine.

Spinal Elements and Mighty Oak Medical to Collaborate on FIREFLY Patient-Matched Surgery Solutions

Spinal Elements and Mighty Oak Medical will co-market the FIREFLY® surgical guidance system, comprising patient-matched bone models and intra-op pedicle screw guides created via 3D printing.

Wright Completes Sale of Tornier Large Joints to Corin

Wright Medical completed the sale of Tornier's hip/knee business to Corin for 29.7MM in cash (~US $32.3MM).

M&A Close-up: 2016 Transactions Year to Date

Strategic transactions year to date in 2016 represent participants from OEMs, Suppliers, Distributors and Private Equity, with values ranging from $10 million to $1 billion.

The Forgotten Phase of M&A: Supply Chain Infrastructure

Avoid disruptions in customer service and financial performance by reviewing the people, processes and supporting systems of upstream and downstream supply chains.

Postmarket Surveillance and M&A

Data collection is paramount to the success of any orthopaedic device. What happens to the much-coveted postmarket data/initiative during and after a merger or acquisition? We posed this question to Vicki Anastasi, Vice President & Global Head, Medical Devices & Diagnostics Research with ICON plc.

Zimmer Biomet to Distribute Nextremity Solutions Products

Zimmer Biomet entered into an exclusive agreement to globally distribute Nextremity Solutions' foot and ankle deformity correction products.

Isto Technologies Acquires Arteriocyte Medical

Isto Technologies acquired Arteriocyte Medical Systems, forming Isto Biologics. The new entity will offer evidence-based solutions for spine and orthopaedic applications. Terms were not disclosed.

Richard Wolf Opens Subsidiary, RIWOspine

Richard Wolf established a RIWOspine subsidiary in Germany to market devices for minimally invasive and endoscopic spine surgery and pain therapy.

InterMed, Z-Medical Enter Distribution Agreement with HealthTrust

InterMed Resources entered into an agreement to distribute Z-Medical's MIS Z-Pedicle Screw to HealthTrust's ~1,600 acute care facilities in the U.S.

Tecomet Acquires Mountainside Medical

Tecomet acquired Mountainside Medical, a manufacturer of instruments for minimally invasive surgery and orthopaedic/neurosurgical implants and instruments.

Alpha Source Named Exclusive U.S. Service Provider for GE Healthcare Bone Mineral Densitometry Products

Alpha Source has transitioned to be the services and exclusive parts provider for GE Healthcare's bone mineral densitometry products in the U.S.

Spineology Expands Relationship with Musculoskeletal Transplant Foundation

The Musculoskeletal Transplant Foundation is now sole tissue provider for Spineology's allograft product lines, including the newly-launched Incite™ Cortical Fiber bone graft.

Tinavi Medical to Distribute Spineway Devices in China

Spineway signed a 5-year agreement with TINAVI Medical for distribution of spinal implants and instruments in China. TINAVI's TiRobot™ is reported to be the only surgical robot capable of addressing surgery on all spinal regions.

Amplitude Surgical Acquires Remaining Interest in Brazilian Subsidiary

Amplitude Surgical acquired the remaining 40% interest in Unimplant, its distribution subsidiary in Brazil.

Zimmer Biomet Acquires Clinical Graphics, 3-D Imaging Provider

Zimmer Biomet acquired Clinical Graphics, a specialist in 3D range-of-motion simulation technology for hip conditions requiring early intervention.

Stryker to Acquire Instratek

Stryker entered into a definitive agreement to acquire Instratek, provider of implants and minimally invasive soft tissue recession instrumentation for foot, ankle and upper extremity procedures.

In2Bones USA Completes Merger to Form i2b Global

In2Bones SAS has merged with In2Bones USA, its largest distributor, to form i2b, a global company serving the upper and lower extremities orthopaedic markets.

SpineVision Acquired by Norgine Ventures

Norgine Ventures entered into a definitive agreement to acquire SpineVision. The partnership will support SpineVision's research and development for commercialization of products combining dynamic stabilization and a minimally invasive, percutaneous approach, such as Flex+2 and LUMIS.

GE to Acquire Additive Manufacturing Companies Arcam and SLM

GE plans to acquire Arcam and SLM Solutions, suppliers of additive manufacturing equipment, for US $1.4BB in cash.

Globus Medical Completes Acquisition of Alphatec’s International Business

Globus Medical completed its acquisition of the international operations and distribution channels of Alphatec Spine for US $80.0MM in cash.

Stryker’s Endoscopy Division Acquires Ivy sports-medicine

Stryker's Endoscopy division acquired Ivy sports-medicine, enabling Stryker to offer a complete meniscal platform.

Ferring Acquires Rights to Seikagaku Treatment for Herniated Disc

Ferring Pharmaceuticals acquired exclusive development and commercialization rights to Seikagaku's SI-6603 injectable condoliase, a potential treatment for lumbar disc herniation, for up to US $95.0MM in upfront cash plus milestone payments.

SeaSpine to Acquire NLT Spine, Expandable Interbody Platform Technologies

SeaSpine entered into a definitive agreement to acquire NLT Spine, developer of minimally invasive surgery devices. SeaSpine's commercial launch of the first NLT product is expected in 1H17.

Zimmer Biomet Acquires CD Diagnostics

Zimmer Biomet acquired CD Diagnostics, developer of immunoassays and biomarker testing to inform treatment decisions. Financial terms were not disclosed.

Biomedical Structures Acquired by Confluent Medical Technologies

Biomedical Structures, manufacturer of biomedical textile implants with application in orthopaedics, was acquired by Confluent Medical Technologies, a contract manufacturer of Nitinol components and kyphoplasty balloons. Terms were not disclosed.

JRI Orthopaedics Acquires Sheffield Medical Products

JRI Orthopaedics acquired Sheffield Medical Products, designer of the AEON cemented total hip.

Globus Medical to Acquire International Business of Alphatec Spine

Globus Medical entered into an agreement to acquire the ex-U.S. operations and distribution channels of Alphatec (ATEC) for US $80.0MM in cash. ATEC posted 2015 ex-U.S. revenue of $70.7MM.

Zimmer Biomet to Acquire Medtech Surgical Robotics Company

Zimmer Biomet announced its plans to acquire Medtech, provider of surgical systems including the ROSA™ Spine robotic-assistive device for minimally invasive surgery.

Corin Orthopaedics to Acquire Wright Medical’s Hip and Knee Assets

Wright Medical received a binding offer under which Corin Orthopaedics would acquire Wright's hip/knee business for 29.7MM in cash (~US $33MM). The proposed transaction is expected to close by early 4Q16.

Merit Medical Acquires DFINE

Merit Medical Systems, manufacturer of proprietary disposable devices used primarily in cardiology, radiology and endoscopy, acquired DFINE in a merger transaction for ~US $97.5MM in cash.

NuVasive Completes Acquistion of Biotronic NeuroNetwork

NuVasive completed its previously-announced acquisition of Biotronic NeuroNetwork, which is now part of the NuVasive Clinical Services division.

1H16 M&A Recap: Big Players Make Moves

During 1H16, seven of the eight largest orthopaedic device companies confirmed or completed acquisitions or divestitures spanning nearly every orthopaedic market segment. Here we present a full list of M&A transactions from the first half of the year.

Zimmer Biomet Acquiring LDR

Zimmer Biomet entered into a definitive agreement to acquire LDR for US $37/share in cash, for a transaction valued at ~$1.0BB with an expected 3Q16 close.

Medtronic Acquires Responsive Orthopedics

Medtronic acquired Responsive Orthopedics, a startup focused on sales of low-cost hip and knee replacements. A primary knee is slated for commercial U.S. availability within 1H17, followed by a primary hip in 1H18.

NuVasive Acquiring Biotronic NeuroNetwork for $98 Million

NuVasive (NUVA) entered into a definitive agreement to acquire Biotronic NeuroNetwork, a U.S. provider of intraoperative neurophysiological monitoring services, for US $98MM in cash.

Mazor Robotics Signs Commercial and Investment Agreements With Medtronic

Mazor Robotics entered into strategic agreements with Medtronic for equity investment and for co-development/potential global distribution of certain Mazor products.

Novastep and Vivex Biomedical to Launch bioSTART Biologics

Novastep signed an agreement with Vivex Biomedical to launch bioSTART® Tissue Repair products, offering amniotic membranes and liquid to support foot and ankle procedures in the U.S.

Zimmer Biomet Completes Acquisition of Cayenne Medical

Zimmer Biomet closed its previously-announced acquisition of Cayenne Medical, a manufacturer of soft tissue repair and reconstruction products for the knee, shoulder and extremities.

Tecres and Keensight to Form Demetra

Demetra Holding has formed with investment from Tecres and Keensight, which acquired aap Implantate's biomaterials assets.

aap Implantate Completes Sale of Biomaterials Unit

aap Implantate completed the sale of its aapBiomaterials subsidiary. The buyer is Keensight Capital.

DePuy Synthes/JNJ Acquiring BioMedical Enterprises

DePuy Orthopaedics has acquired BioMedical Enterprises, a manufacturer of Nitinol orthopaedic implants for small bone fixation to treat bunions, hammertoes, hand/wrist deformities, etc.

Histogenics Acquires Rights to NeoCart for the Japanese Market

Histogenics acquired development and commercialization rights to NeoCart® for the Japanese market from its partner, Purpose Co. NeoCart autologous cell therapy is designed to treat knee cartilage defects.

Majority Ownership of Amendia Purchased by Private Equity Firm

Private equity firm Kohlberg & Company has acquired majority ownership of Amendia, and will support its growth initiatives from a US $1.6BB private equity fund.

Stryker Acquires Stanmore Implants

Stryker acquired Stanmore Implants Worldwide in an all-cash transaction for £35.6MM (~US $52MM). Stanmore Implants' portfolio comprises patient-specific and off-the-shelf implant systems for limb salvage.

Zimmer Biomet to Acquire Cayenne Medical

Zimmer Biomet entered into a definitive agreement to acquire Cayenne Medical within 2Q16. Terms of the transaction were not disclosed.

BD Divests Vertebral Augmentation Products to Stryker

BD sold its vertebral augmentation assets, including all AVAmax®, AVAflex®, AVAtex® and AVAprep® branded products, to Stryker. Financial terms were not disclosed.

LISI Medical to Acquire Alcoa Remmele

LISI Medical, a contract manufacturer, signed an agreement to acquire Alcoa Remmele for 90MM (~US $102MM). The transaction is expected to close in 2Q16. Remmele posted 2015 revenue of $70MM.

Stryker Acquires SafeWire Portfolio for Minimally Invasive Spine Procedures

Stryker Spine acquired SafeWire's product portfolio, including the Y-Wire guidewire and Tiger Jamshidi Needle for use in minimally invasive spine surgery.

Vivex Biomedical and Arthrex Enter into Long Term Agreement

Vivex Biomedical and Arthrex signed a new multi-year agreement expanding the breadth of Vivex's products for Arthrex's distribution.

aap Implantate Divests Biomaterials Unit

aap Implantate sold its biomaterials unit to an undisclosed private equity firm for 36MM (~US $40.3MM). Upon closing, aap will proceed as a pure-play trauma entity.

In’Tech Medical Acquires Ortho Solutions in Asia

In'Tech Medical acquired Ortho Solutions, a contract manufacturer of orthopaedic implants and instruments in Asia.

Intellijoint Surgical Partners with Corin

Intellijoint Surgical entered into a strategic partnership with Corin for Australia distribution of the intellijoint HIP™, to complement Corin's Optimized Positioning System™ technology.

OrthoSensor in Strategic Partnership with Electronics Company IM-Tech

OrthoSensor entered into a partnership with IM-Tech to support R&D collaboration, manufacturing and investments in electronics technology in the global commercialization of the VERASENSE™ sensor.

NuVasive to Acquire Mega Surgical, Brazilian Distributor

NuVasive entered into a definitive agreement to acquire Mega Surgical, its exclusive distributor in Brazil. The transaction is expected to close within 1Q16.

Joint Active Systems Acquiring Empi Advance ROM Braces

Joint Active Systems signed a non-binding letter of intent to acquire the Empi® Advance® ROM line of dynamic braces.

EOS imaging and Stryker in Co-promotion Agreement for U.K. Market

EOS imaging entered into a co-promotion agreement whereby Stryker's European Spine business will promote EOS imaging's platform to existing and prospective customers in the U.K.

Lima Corporate Enters Alliance with Hospital for Special Surgery

Lima Corporate entered into an Innovation Alliance Agreement with the Hospital for Special Surgery. New product co-developments include a Trabecular Titanium total elbow and an advanced acetabular cup.

EQT, Hansjorg Wyss New Owners of Lima Corporate

EQT, a global private equity group, with Hansjörg Wyss as co-investor, has completed acquisition of the majority of shares of Lima Corporate.

LifeNet Health, Arthrex Extend Collaboration

LifeNet Health and Arthrex signed a new long-term agreement to provide allograft implants and instrumentation to surgeons and explore new applications, such as opportunities in cartilage repair.

Invibio and Maxx Orthopedics to Co-develop PEEK-based Knee

Invibio Knee partnered with Maxx Orthopedics to develop a PEEK-OPTIMA®-based femoral knee replacement.

Bone Therapeutics Extends Collaboration with Kasios

Bone Therapeutics extended its collaboration with Kasios to combine ALLOB® bone cell therapy with a 3D-printed synthetic cage intended to support the spinal fusion process.

Exactech Acquires its Independent Australia Distributor

Exactech acquired Exactech Australia, an independent importer and distributor of Exactech's orthopaedic implants, instrumentation and surgical technology.

CTL Acquires AccelSPINE

CTL Medical, a medical device manufacturing and services company, signed a definitive agreement to acquire AccelSPINE.

Bioventus Boosts Orthobiologics Business with Acquisitions

Bioventus spent most of 2015 building an infrastructure to expand its surgical business. With trecent acqusitions, a sales and distribution plan in place and future plans for inorganic and organic growth, Bioventus executives now say that the company is positioning itself as an orthobiologics leader.

EOS Imaging partners with Spinologics on Surgical Simulation

EOS imaging partnered with Spinologics to co-develop biomechanical spine surgery simulation tools for integration with EOS imaging's cloud-based, 3D planning software.

Kuros Biosurgery Completes Merger With Cytos Biotechnology

Kuros Biosurgery closed its previously-announced transaction merging Kuros with Cytos Biotechnology, to form Kuros Biosciences.

MiMedx Closes Acquisition of Stability Biologics

MiMedx completed its acquisition of Stability Biologics, provider of human tissue products serving the surgical, spine and orthopaedic sectors. Stability Biologics will operate as a wholly-owned subsidiary of MiMedx.

Smith & Nephew Acquires BST-CarGel from Piramal

Smith & Nephew acquired BST-CarGel® cartilage repair product and IP assets from Piramal. Transaction terms were not disclosed.

MiMedx to Acquire Stability Biologics

MiMedx signed a definitive agreement to acquire Stability Biologics for US $10MM in cash and stock. Stability Biologics provides human tissue products for the surgical, spine and orthopaedic industries. The transaction is expected to close in early 1Q16.

Smith+Nephew Completes Acquisition of Blue Belt Technologies

Smith+Nephew completed its acquisition of Blue Belt Technologies, developer of the Navio surgical robotics-assistance system for unicondylar knee replacement.

NuVasive to Acquire Ellipse Technologies

NuVasive entered into a definitive agreement to acquire Ellipse Technologies for US $380MM in cash, with a potential $30MM milestone payable in 2017. The transaction is slated to close in mid-1Q16. Ellipse posted 2015 revenue of ~$40MM, +54% vs. 2014.