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CartiHeal's Agili-C Implant In-vitro Study Results -

In vitro study results suggest that CartiHeal's Agili-C™ implant can enhance osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (MSCs). Agili-C device is a porous, biocompatible and resorbable bi-phasic aragonite-based scaffold made of interconnected natural inorganic calcium carbonate. The study investigated mechanisms induced by the bone phase of the implant on the osteogenic differentiation of bone marrow-derived MSCs when cultured under differentiation-inducing conditions. Results demonstrated that the bone phase of the bi-phasic scaffold supports bone-forming differentiation and enhanced proliferation of the MSCs at molecular and histological levels. The scaffold was colonized by differentiating MSCs, suggesting suitability for use in bone voids to accelerate healing. The mechanism of osteogenic differentiation was found to involve scaffold surface modification with de-novo production of calcium phosphate deposits. This novel coral-based scaffold may promote the rapid formation of high-quality bone during the repair of osteochondral lesions. (CartiHeal, 5/30/19)